Ongoing Degenerative Myelopathy Research: The genetic picture grows more complex - MyCorgi.com2024-03-28T23:16:50Zhttp://mycorgi.com/forum/topics/ongoing-degenerative-myelopathy-research-the-genetic-picture?commentId=1150197%3AComment%3A1806150&x=1&feed=yes&xn_auth=noAs the other said, thank you…tag:mycorgi.com,2013-10-03:1150197:Comment:18061502013-10-03T07:19:24.518ZGromit, Sparkle, and Doughttp://mycorgi.com/profile/DougKlassen
<p>As the other said, thank you for taking the time to summarize a complicated subject for us, Beth. I lost my beloved <a href="http://www.corgifan.com/tinsel/" target="_blank">Tinsel</a> to DM four years ago come November. It's a long, heartbreaking experience to lose a beloved pet to DM. My pal Gromit is DM at risk and I knew that when I got him, but someone had to raise him and love him and I figured it might as well be me.</p>
<p>As the other said, thank you for taking the time to summarize a complicated subject for us, Beth. I lost my beloved <a href="http://www.corgifan.com/tinsel/" target="_blank">Tinsel</a> to DM four years ago come November. It's a long, heartbreaking experience to lose a beloved pet to DM. My pal Gromit is DM at risk and I knew that when I got him, but someone had to raise him and love him and I figured it might as well be me.</p> Please keep us updated with a…tag:mycorgi.com,2013-10-03:1150197:Comment:18061392013-10-03T02:14:41.618ZJenny, Tucker, & Zoeyhttp://mycorgi.com/profile/jenny
<p>Please keep us updated with any new info you come across. I decided to do the DNA test on Tucker and Zoey. Just got the results back and Zoey is only a carrier, but Tucker is "at-risk". </p>
<p>Please keep us updated with any new info you come across. I decided to do the DNA test on Tucker and Zoey. Just got the results back and Zoey is only a carrier, but Tucker is "at-risk". </p> Really interesting. I haven't…tag:mycorgi.com,2013-09-24:1150197:Comment:18038292013-09-24T04:44:43.581ZMelissa and Franklin!http://mycorgi.com/profile/Melissa919
<p>Really interesting. I haven't read the whole article but it is definitely something that should be read by breeders and buyers alike.</p>
<p>Really interesting. I haven't read the whole article but it is definitely something that should be read by breeders and buyers alike.</p> Thank you for posting this Be…tag:mycorgi.com,2013-09-23:1150197:Comment:18033302013-09-23T00:47:55.936ZJanehttp://mycorgi.com/profile/Jane944
<p>Thank you for posting this Beth. Very useful information.</p>
<p>Thank you for posting this Beth. Very useful information.</p> Once they narrow down the gen…tag:mycorgi.com,2013-09-22:1150197:Comment:18030872013-09-22T22:31:38.879ZBethhttp://mycorgi.com/profile/Beth306
<p>Once they narrow down the genes responsible in the Clear dogs who had DM, it would be interesting to see if some of the earlier diagnosed dogs have the other mutations as well. </p>
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<p>In breeds with a higher prevalence of the gene, it is easy to assume that all who get it who also are AA have it BECAUSE of the AA variant. But if they also carry the OTHER mutation, well then who can say? </p>
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<p>DM is relatively common (in the area of 2%) in German Shepherds, and they…</p>
<p>Once they narrow down the genes responsible in the Clear dogs who had DM, it would be interesting to see if some of the earlier diagnosed dogs have the other mutations as well. </p>
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<p>In breeds with a higher prevalence of the gene, it is easy to assume that all who get it who also are AA have it BECAUSE of the AA variant. But if they also carry the OTHER mutation, well then who can say? </p>
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<p>DM is relatively common (in the area of 2%) in German Shepherds, and they carry a high rate of the original mutation, yet one of the dogs who was Clear but got DM was a GSD. I think the other was a Bernese Mountain Dog, and of the Carriers who got the disease, one was a Chessie but I haven't found what the others are.</p>
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<p>The funny thing about genetic code is there are lots of redundancies, and multiple ways to achieve the same end.</p>
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<p>What I also found interesting was that on paper, Wire Fox Terriers are a very high at-risk breed, yet none of them get it. They must only have "good" copies of whatever modifier genes are out there in their gene pool.</p>
<p></p> You are welcome! I try to ke…tag:mycorgi.com,2013-09-22:1150197:Comment:18029212013-09-22T22:26:42.778ZBethhttp://mycorgi.com/profile/Beth306
<p>You are welcome! I try to keep up with the research, both because it matters to Corgi owners and because I generally find that sort of research very interesting in its own right; I'm one of those people who always reads the health news in the paper and online.</p>
<p>You are welcome! I try to keep up with the research, both because it matters to Corgi owners and because I generally find that sort of research very interesting in its own right; I'm one of those people who always reads the health news in the paper and online.</p> I hope she doesn't too. It's…tag:mycorgi.com,2013-09-22:1150197:Comment:18030852013-09-22T22:25:54.769ZBethhttp://mycorgi.com/profile/Beth306
<p>I hope she doesn't too. It's hard to get accurate stats, but the best I can find is that about 1.5% of Pems presenting at veterinary hospitals have DM, which means the actual incidence is probably a bit lower than that (since a fair number don't take their dogs to vets, and the symptoms are severe enough that under-diagnosis is not likely an issue). About half of all Pems are At Risk with the gene. </p>
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<p>So if we assume that all the Pems who get DM carry the At Risk set of…</p>
<p>I hope she doesn't too. It's hard to get accurate stats, but the best I can find is that about 1.5% of Pems presenting at veterinary hospitals have DM, which means the actual incidence is probably a bit lower than that (since a fair number don't take their dogs to vets, and the symptoms are severe enough that under-diagnosis is not likely an issue). About half of all Pems are At Risk with the gene. </p>
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<p>So if we assume that all the Pems who get DM carry the At Risk set of genes (and that may very well not be true, if indeed it turns out that there are some other mutations that cause it), that means that only about 3% of Pems who are At Risk will ever get the disease.</p>
<p><br/>The odds are probably a bit lower than that if there are no immediate relatives who ever had DM, and higher than that if there are, but still the odds are well in your favor. </p>
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<p>And remember, there are many breeds that carry the gene, and even mixed breeds. We know a Pug in a cart who has DM and has done fairly well for awhile, though things have gotten worse recently.</p> Thanks Beth, this is really i…tag:mycorgi.com,2013-09-22:1150197:Comment:18030722013-09-22T17:41:55.146ZJohn Wolffhttp://mycorgi.com/profile/JohnWolff92
<p>Thanks Beth, this is really interesting. Once I get time to read it all, I'll pass it on to my boss (human hereditary neurologic diseases being his specialty; probably already read it). The canine stuff is highly relevant to human disease.</p>
<p>It's noteworthy how things that look so simple in the textbook (think Mendelian genetics) turn out to be so complicated in real life.</p>
<p>Thanks Beth, this is really interesting. Once I get time to read it all, I'll pass it on to my boss (human hereditary neurologic diseases being his specialty; probably already read it). The canine stuff is highly relevant to human disease.</p>
<p>It's noteworthy how things that look so simple in the textbook (think Mendelian genetics) turn out to be so complicated in real life.</p> thanks for sharing all this i…tag:mycorgi.com,2013-09-22:1150197:Comment:18030642013-09-22T14:46:21.224ZLaura and Tommy Jeffersonhttp://mycorgi.com/profile/LauraB
<p>thanks for sharing all this info, Beth! </p>
<p>thanks for sharing all this info, Beth! </p> Ein has the gene that makes h…tag:mycorgi.com,2013-09-22:1150197:Comment:18030502013-09-22T04:42:51.996ZIngrid & Einhttp://mycorgi.com/profile/IngridBotto
<p>Ein has the gene that makes her at-risk for DM. (I didn't have her tested for it, but her breeder did when the test became available. I got her as adult, and the breeder let me know before I bought her). I sure hope she never gets DM :(</p>
<p>Ein has the gene that makes her at-risk for DM. (I didn't have her tested for it, but her breeder did when the test became available. I got her as adult, and the breeder let me know before I bought her). I sure hope she never gets DM :(</p>